Long-term effects of foetal undernutrition on intermediary metabolism in growing lambs
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
The objective of this study was to investigate the effects of foetal undernutrition on the metabolism in growing lambs. Seven-month-old lambs whose nothers had been fed either restrictively (RN; n = 14) or adequately (AN; n = 6) in late gestation were fasted for three days. One hour before fasting and after 48 h and 72 h fasting, changes in plasma concentrations of metabolites, i.e. glucose, non-esterified fatty acids (NEFA), 3-ß-hydroxybutyrate (BOHB) and urea as well as hormones, i.e. insulin, the insulin-like growth factor (IGF-I) and leptin, were determined. Blood glucose, NEFA, urea, insulin, IGF-I and leptin were not different between the two groups of lambs. Unexpectedly, at the end of the 3 d fasting, in spite of lower NEFA concentration (1.6 ± 0.03 vs. 1.9 ± 0.05 mM in Groups RN and AN, respectively), the BOHB concentration in RN lambs (0.94 ± 0.02 mM) was significantly higher than that in AN lambs (0.78 ± 0.04 mM). This higher rate of BOHB production might be interpreted as perturbations in etone body metabolism potentially induced by under-nutrition during foetal life. However, more investigations are necessary to clarify this interrelationship.
Originalsprog | Engelsk |
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Tidsskrift | Archives of Animal Nutrition |
Vol/bind | 65 |
Udgave nummer | 1 |
Sider (fra-til) | 46-54 |
Antal sider | 9 |
ISSN | 1745-039X |
DOI | |
Status | Udgivet - 2011 |
- Det tidligere LIFE - metabolic programming, metabolites, fasting, sheep
Forskningsområder
ID: 32351113