Virulence Factors for Hemolytic Uremic Syndrome, Denmark
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
We present an analysis of strain and patient factors associated with the development of bloody diarrhea and hemolytic uremic syndrome (HUS) among Shiga toxin-producing Escherichia coli (STEC) patients registered in Denmark in a 6-year period. Of 343 STEC patients, bloody diarrhea developed in 36.4% and HUS in 6.1%. In a multivariate logistic regression model, risk factors for bloody diarrhea were the eae and stx2 genes, O groups 0157 and O103, and increasing age. Risk factors for HUS were presence of the stx2 (odds ratio [OR] 18.9) and eae (OR undefined) genes, being a child, and having bloody diarrhea. O group O157, although associated with HUS in a univariate analysis (OR 4.0), was not associated in the multivariate analysis (OR 1.1). This finding indicates that, rather than the O group, the combined presence of the eae and stx2 genes is an important predictor of HUS.
Originalsprog | Engelsk |
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Tidsskrift | Emerging Infectious Diseases |
Vol/bind | 10 |
Udgave nummer | 5 |
Sider (fra-til) | 842-847 |
Antal sider | 6 |
ISSN | 1080-6040 |
DOI | |
Status | Udgivet - 1 jan. 2004 |
ID: 203887662