Nanoparticles of carbon allotropes inhibit glioblastoma multiforme angiogenesis in ovo
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Nanoparticles of carbon allotropes inhibit glioblastoma multiforme angiogenesis in ovo. / Grodzik, Marta; Sawosz, Ewa; Wierzbicki, Mateusz; Orlowski, Piotr; Hotowy, Anna Malgorzata; Niemiec, Tomasz; Szmidt, Maciej; Mitura, Katarzyna; Chwalibog, André.
I: International Journal of Nanomedicine (Online), Bind 6, 2011, s. 3041-3048.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Nanoparticles of carbon allotropes inhibit glioblastoma multiforme angiogenesis in ovo
AU - Grodzik, Marta
AU - Sawosz, Ewa
AU - Wierzbicki, Mateusz
AU - Orlowski, Piotr
AU - Hotowy, Anna Malgorzata
AU - Niemiec, Tomasz
AU - Szmidt, Maciej
AU - Mitura, Katarzyna
AU - Chwalibog, André
PY - 2011
Y1 - 2011
N2 - The objective of the study was to determine the effect of carbon nanoparticles produced by different methods on the growth of brain tumor and the development of blood vessels. Glioblastoma multiforme cells were cultured on the chrioallantoic membrane of chicken embryo and after 7 days of incubation, were treated with carbon nanoparticles administered in ovo to the tumor. Both types of nanoparticles significantly decreased tumor mass and volume, fibroblast growth factor-2 and vascular endothelial growth factor expression at the messenger ribonucleic acid level. The present results demonstrate antiangiogenic activity of carbon nanoparticles, making them potential factors for anticancer therapy.
AB - The objective of the study was to determine the effect of carbon nanoparticles produced by different methods on the growth of brain tumor and the development of blood vessels. Glioblastoma multiforme cells were cultured on the chrioallantoic membrane of chicken embryo and after 7 days of incubation, were treated with carbon nanoparticles administered in ovo to the tumor. Both types of nanoparticles significantly decreased tumor mass and volume, fibroblast growth factor-2 and vascular endothelial growth factor expression at the messenger ribonucleic acid level. The present results demonstrate antiangiogenic activity of carbon nanoparticles, making them potential factors for anticancer therapy.
KW - Former LIFE faculty
KW - cancer
KW - nanoparticle
KW - embryo
KW - angiogenesis
KW - FGF-2
KW - VEGF
U2 - 10.2147/IJN.S25528
DO - 10.2147/IJN.S25528
M3 - Journal article
VL - 6
SP - 3041
EP - 3048
JO - International Journal of Nanomedicine
JF - International Journal of Nanomedicine
SN - 1176-9114
ER -
ID: 35371504