Effects of ATP-induced leg vasodilation on VO2 peak and leg O2 extraction during maximal exercise in humans
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Effects of ATP-induced leg vasodilation on VO2 peak and leg O2 extraction during maximal exercise in humans. / Calbet, J A L; Lundby, C; Sander, M; Robach, P; Saltin, B; Boushel, Robert Christopher.
I: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Bind 291, Nr. 2, 01.08.2006, s. R447-53.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Effects of ATP-induced leg vasodilation on VO2 peak and leg O2 extraction during maximal exercise in humans
AU - Calbet, J A L
AU - Lundby, C
AU - Sander, M
AU - Robach, P
AU - Saltin, B
AU - Boushel, Robert Christopher
PY - 2006/8/1
Y1 - 2006/8/1
N2 - During maximal whole body exercise VO2 peak is limited by O2 delivery. In turn, it is though that blood flow at near-maximal exercise must be restrained by the sympathetic nervous system to maintain mean arterial pressure. To determine whether enhancing vasodilation across the leg results in higher O2 delivery and leg VO2 during near-maximal and maximal exercise in humans, seven men performed two maximal incremental exercise tests on the cycle ergometer. In random order, one test was performed with and one without (control exercise) infusion of ATP (8 mg in 1 ml of isotonic saline solution) into the right femoral artery at a rate of 80 microg.kg body mass-1.min-1. During near-maximal exercise (92% of VO2 peak), the infusion of ATP increased leg vascular conductance (+43%, P
AB - During maximal whole body exercise VO2 peak is limited by O2 delivery. In turn, it is though that blood flow at near-maximal exercise must be restrained by the sympathetic nervous system to maintain mean arterial pressure. To determine whether enhancing vasodilation across the leg results in higher O2 delivery and leg VO2 during near-maximal and maximal exercise in humans, seven men performed two maximal incremental exercise tests on the cycle ergometer. In random order, one test was performed with and one without (control exercise) infusion of ATP (8 mg in 1 ml of isotonic saline solution) into the right femoral artery at a rate of 80 microg.kg body mass-1.min-1. During near-maximal exercise (92% of VO2 peak), the infusion of ATP increased leg vascular conductance (+43%, P
KW - Adenosine Triphosphate
KW - Adult
KW - Blood Pressure
KW - Body Temperature
KW - Exercise
KW - Humans
KW - Leg
KW - Male
KW - Oxygen Consumption
KW - Vasodilation
U2 - 10.1152/ajpregu.00746.2005
DO - 10.1152/ajpregu.00746.2005
M3 - Journal article
C2 - 16914431
VL - 291
SP - R447-53
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0363-6119
IS - 2
ER -
ID: 33816399