A recombinant antibody with the antigen-specific, major histocompatibility complex-restricted specificity of T cells

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Standard

A recombinant antibody with the antigen-specific, major histocompatibility complex-restricted specificity of T cells. / Andersen, P S; Stryhn, A; Hansen, B E; Fugger, L; Engberg, J; Buus, S.

I: Proceedings of the National Academy of Science of the United States of America, Bind 93, Nr. 5, 1996, s. 1820-4.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Andersen, PS, Stryhn, A, Hansen, BE, Fugger, L, Engberg, J & Buus, S 1996, 'A recombinant antibody with the antigen-specific, major histocompatibility complex-restricted specificity of T cells', Proceedings of the National Academy of Science of the United States of America, bind 93, nr. 5, s. 1820-4.

APA

Andersen, P. S., Stryhn, A., Hansen, B. E., Fugger, L., Engberg, J., & Buus, S. (1996). A recombinant antibody with the antigen-specific, major histocompatibility complex-restricted specificity of T cells. Proceedings of the National Academy of Science of the United States of America, 93(5), 1820-4.

Vancouver

Andersen PS, Stryhn A, Hansen BE, Fugger L, Engberg J, Buus S. A recombinant antibody with the antigen-specific, major histocompatibility complex-restricted specificity of T cells. Proceedings of the National Academy of Science of the United States of America. 1996;93(5):1820-4.

Author

Andersen, P S ; Stryhn, A ; Hansen, B E ; Fugger, L ; Engberg, J ; Buus, S. / A recombinant antibody with the antigen-specific, major histocompatibility complex-restricted specificity of T cells. I: Proceedings of the National Academy of Science of the United States of America. 1996 ; Bind 93, Nr. 5. s. 1820-4.

Bibtex

@article{dacfa540ebcc11ddbf70000ea68e967b,
title = "A recombinant antibody with the antigen-specific, major histocompatibility complex-restricted specificity of T cells",
abstract = "Specific recognition of peptide/major histocompatibility complex (MHC) molecule complexes by the T-cell receptor is a key reaction in the specific immune response. Antibodies against peptide/MHC complexes would therefore be valuable tools in studying MHC function and T-cell recognition and might lead to novel approaches in immunotherapy. However, it has proven difficult to generate antibodies with the specificity of T cells by conventional hybridoma techniques. Here we report that the phage display technology is a feasible alternative to generate antibodies recognizing specific, predetermined peptide/MHC complexes.",
author = "Andersen, {P S} and A Stryhn and Hansen, {B E} and L Fugger and J Engberg and S Buus",
note = "Keywords: Amino Acid Sequence; Animals; Antibody Specificity; Bacteriophages; Gene Library; Major Histocompatibility Complex; Mice; Mice, Inbred AKR; Molecular Sequence Data; Peptides; Recombinant Proteins; T-Lymphocytes",
year = "1996",
language = "English",
volume = "93",
pages = "1820--4",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "The National Academy of Sciences of the United States of America",
number = "5",

}

RIS

TY - JOUR

T1 - A recombinant antibody with the antigen-specific, major histocompatibility complex-restricted specificity of T cells

AU - Andersen, P S

AU - Stryhn, A

AU - Hansen, B E

AU - Fugger, L

AU - Engberg, J

AU - Buus, S

N1 - Keywords: Amino Acid Sequence; Animals; Antibody Specificity; Bacteriophages; Gene Library; Major Histocompatibility Complex; Mice; Mice, Inbred AKR; Molecular Sequence Data; Peptides; Recombinant Proteins; T-Lymphocytes

PY - 1996

Y1 - 1996

N2 - Specific recognition of peptide/major histocompatibility complex (MHC) molecule complexes by the T-cell receptor is a key reaction in the specific immune response. Antibodies against peptide/MHC complexes would therefore be valuable tools in studying MHC function and T-cell recognition and might lead to novel approaches in immunotherapy. However, it has proven difficult to generate antibodies with the specificity of T cells by conventional hybridoma techniques. Here we report that the phage display technology is a feasible alternative to generate antibodies recognizing specific, predetermined peptide/MHC complexes.

AB - Specific recognition of peptide/major histocompatibility complex (MHC) molecule complexes by the T-cell receptor is a key reaction in the specific immune response. Antibodies against peptide/MHC complexes would therefore be valuable tools in studying MHC function and T-cell recognition and might lead to novel approaches in immunotherapy. However, it has proven difficult to generate antibodies with the specificity of T cells by conventional hybridoma techniques. Here we report that the phage display technology is a feasible alternative to generate antibodies recognizing specific, predetermined peptide/MHC complexes.

M3 - Journal article

C2 - 8700842

VL - 93

SP - 1820

EP - 1824

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 5

ER -

ID: 9945624